Validating survivin as a cancer therapeutic target

Acquisition of the ability to evade cellular suicide, or apoptosis, is one of the master switches that contributes to cellular transformation and, to invasive cancer

Dario C. Altieri

2003

Scholarcy highlights

  • Acquisition of the ability to evade cellular suicide, or apoptosis, is one of the master switches that contributes to cellular transformation and, to invasive cancer
  • A stress-induced protein kinase that has been implicated in cell death or cell viability, depending on the cellular context, and is activated by XIAP
  • The phosphatidylinositol 3-kinase family of enzymes are activated in response to a wide variety of stimuli and catalyse the phophorylation of inositol lipids at the D-3 position of the inositol ring. These phosphoinositides act as second messengers; a primary target is the serine/threonine kinase AKT
  • Activated AKT phosphorylates several cellular targets, including proteins that are involved in cell survival, proliferation and migration
  • MRNA transcripts identified by serial analysis of gene expression that are selectively expressed in human tumours but undetectable or found at very low levels in normal tissues that are isolated from the same organs
  • Deregulated signalling through Wnt/T-cell factor/β-catenin has been implicated in a variety of human tumours, most notably colon cancer, potentially by deregulating the balance between cell proliferation/cell differentiation in stem-cell compartments
  • Regions with high frequency of LOH are believed to harbour tumour-suppressor genes

Need more features? Save interactive summary cards to your Scholarcy Library.