DNA damage and the balance between survival and death in cancer biology

In this Review, we describe key decision-making nodes in the complex interplay between cell survival and death following DNA damage

Wynand P. Roos; Adam D. Thomas; Bernd Kaina

2015

Scholarcy highlights

  • The importance of caspase cleavage of Beclin 1 in the switch between autophagy and apoptosis is demonstrated in this paper
  • These authors described for the first time that apoptosis is an important cell death mechanism
  • A regulated, non-apoptotic form of cell death that is dependent on iron
  • It triggers apoptosis in a DNA damage-independent manner

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