A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy

We show that graphene doped with gold and combined with a gold mesh has improved electrochemical activity over bare graphene, sufficient to form a wearable patch for sweat-based diabetes monitoring and feedback therapy

Hyunjae Lee; Tae Kyu Choi; Young Bum Lee; Hye Rim Cho; Roozbeh Ghaffari; Liu Wang; Hyung Jin Choi; Taek Dong Chung; Nanshu Lu; Taeghwan Hyeon; Seung Hong Choi; Dae-Hyeong Kim

2016

Scholarcy highlights

  • Owing to its high carrier mobility, conductivity, flexibility and optical transparency, graphene is a versatile material in micro- and macroelectronics
  • The low density of electrochemically active defects in graphene synthesized by chemical vapour deposition limits its application in biosensing
  • We show that graphene doped with gold and combined with a gold mesh has improved electrochemical activity over bare graphene, sufficient to form a wearable patch for sweat-based diabetes monitoring and feedback therapy
  • The stretchable device features a serpentine bilayer of gold mesh and gold-doped graphene that forms an efficient electrochemical interface for the stable transfer of electrical signals
  • The patch consists of a heater, temperature, humidity, glucose and pH sensors and polymeric microneedles that can be thermally activated to deliver drugs transcutaneously
  • We show that the patch can be thermally actuated to deliver Metformin and reduce blood glucose levels in diabetic mice

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