Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

We show that two independent loss-of-function genetic variants in the gene encoding filaggrin are very strong predisposing factors for atopic dermatitis

Colin N A Palmer

2006

Scholarcy highlights

  • Atopic disease, including atopic dermatitis, allergy and asthma, has increased in frequency in recent decades1 and affects ∼20% of the population in the developed world
  • We show that two independent loss-of-function genetic variants in the gene encoding filaggrin are very strong predisposing factors for atopic dermatitis
  • Colin N A Palmer and Alan D Irvine: These authors contributed to this work

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