Reconciling the chemistry and biology of reactive oxygen species

This review addresses this gap

Christine C Winterbourn

2008

Scholarcy highlights

  • There is a vast literature on the generation and effects of reactive oxygen species in biological systems, both in relation to damage they cause and their involvement in cell regulatory and signaling pathways
  • The biological chemistry of different oxidants is becoming well understood, but it is often unclear how this translates into cellular mechanisms where redox changes have been demonstrated
  • It examines how target selectivity and antioxidant effectiveness vary for different oxidants
  • Kinetic considerations of reactivity are used to assess likely targets in cells and how reactions might be influenced by restricted diffusion and compartmentalization
  • It highlights areas where greater understanding is required on the fate of oxidants generated by cellular NADPH oxidases and on the identification of oxidant sensors in cell signaling

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