Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

We demonstrate here that S1P1 receptors activated by FTY720P retain signaling activity for hours in spite of a quantitative internalization

Florian Mullershausen; Frédéric Zecri; Cihan Cetin; Andreas Billich; Danilo Guerini; Klaus Seuwen

2009

Scholarcy highlights

  • Targeting sphingosine-1-phosphate receptors with the oral immunomodulator drug FTY720 has demonstrated substantial efficacy in the treatment of multiple sclerosis
  • The error has been corrected in the HTML and PDF versions of the article
  • R. et al Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer
  • K.S. conceived and designed experiments and wrote the manuscript

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