Mesodermal Wnt2b signalling positively regulates liver specification

liver and pancreas emerge at precise locations along the primitive gut tube

Elke A. Ober; Heather Verkade; Holly A. Field; Didier Y. R. Stainier

2006

Scholarcy highlights

  • liver and pancreas emerge at precise locations along the primitive gut tube
  • signalling pathways have been implicated in liver formation
  • the onset of liver specification is marked by the localized endodermal expression of hhex
  • we used a screen for mutations affecting endodermal organ morphogenesis to identify a unique phenotype
  • Positional cloning reveals that prt encodes a
  • The authors declare no competing financial interests

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