Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs

Twenty-six healthy subjects from 19 to 85 yr old took single 15-mg doses of flurazepam

David J Greenblatt

2010

Scholarcy highlights

  • Twenty-six healthy subjects from 19 to 85 yr old took single 15-mg doses of flurazepam
  • For the first 6 to 8 hr after drug, several additional FLZ metabolites appeared in plasma, but only DAFLZ was detected from 12 hr onward
  • Blood samples were drawn during FLZ dosage and in the withdrawal period, and morning self-ratings of mood and sleep patterns were obtained using visual analogue scales
  • Single-dose t½ correlated with washout t½ after termination of FLZ treatment
  • Clinical self-ratings indicated increases over time in perception of morning sedation; changes slowly reverted to baseline in the week after dosage
  • Sleep parameters returned to baseline with a suggestion of “overshoot” sleep disturbance at days 5 and 7 after drug
  • Subjects did not perceive any impairment of intellectual function or motor performance, and no other adverse reactions were reported

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