Prognostic factors in elderly patients with malignant pleural mesothelioma: results of a multicenter survey

We have previously reported the results of a combined analysis of two phase II trials of carboplatin and pemetrexed as first-line therapy in 178 malignant pleural mesothelioma patients: in that study, pooled data of the two trials were retrospectively analysed for comparison between age groups

G L Ceresoli


Scholarcy highlights

  • The incidence of malignant pleural mesothelioma in elderly patients is increasing
  • Non-epithelioid histology, age X75 years, advanced stage and CCIX1 were associated to a shorter overall survival
  • Treatment with pemetrexed was associated with improved OS
  • Non-epithelioid histology, age X75 years, advanced International Mesothelioma Interest Group stage and presence of comorbidities according to Charlson Comorbidity Index were significant prognostic factors in elderly patients with MPM
  • Prospective dedicated trials in MPM elderly patients selected according to prognostic factors including comorbidity scales are warranted
  • Out of a total of 715 consecutive MPM cases diagnosed at the six participating Hospitals in the study period, 241 elderly patients with complete clinical data were identified
  • Owing to the long latent period following exposure, malignant pleural mesothelioma is often diagnosed late in life

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