Single-mismatch detection using gold-quenched fluorescent oligonucleotides

We describe a hybrid material composed of a single-stranded DNA molecule, a 1.4 nm diameter gold nanoparticle, and a fluorophore that is highly quenched by the nanoparticle through a distance-dependent process

Benoit Dubertret; Michel Calame; Albert J. Libchaber

2002

Key concepts

Scholarcy highlights

  • We describe a hybrid material composed of a single-stranded DNA molecule, a 1.4 nm diameter gold nanoparticle, and a fluorophore that is highly quenched by the nanoparticle through a distance-dependent process
  • Stettler was instrumental in the final writing of this manuscript
  • We thank the reviewers for improvement to the manuscript

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