High density synthetic oligonucleotide arrays

We have developed an approach in which sequence information is used directly to design high–density, two–dimensional arrays of synthetic oligonucleotides

Robert J. Lipshutz; Stephen P.A. Fodor; Thomas R. Gingeras; David J. Lockhart

2002

Scholarcy highlights

  • Experimental genomics involves taking advantage of sequence information to investigate and understand the workings of genes, cells and organisms
  • We have developed an approach in which sequence information is used directly to design high–density, two–dimensional arrays of synthetic oligonucleotides
  • We describe the fabrication of the arrays, their design and some specific applications to high–throughput genetic and cellular analysis

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