Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

We report here the identification and characterization of a transmembrane protein, Tim-3, which contains an immunoglobulin and a mucin-like domain and is expressed on differentiated Th1 cells

Laurent Monney; Catherine A. Sabatos; Jason L. Gaglia; Akemi Ryu; Hanspeter Waldner; Tatyana Chernova; Stephen Manning; Edward A. Greenfield; Anthony J. Coyle; Raymond A. Sobel; Gordon J. Freeman; Vijay K. Kuchroo

2002

Scholarcy highlights

  • Activation of naive CD4+ T-helper cells results in the development of at least two distinct effector populations, Th1 and Th2 cells
  • We report here the identification and characterization of a transmembrane protein, Tim-3, which contains an immunoglobulin and a mucin-like domain and is expressed on differentiated Th1 cells
  • Cantor for comments on this manuscript; R

Need more features? Save interactive summary cards to your Scholarcy Library.