A model for p53-induced apoptosis

As the most well documented biochemical property of p53 is its ability to activate transcription of genes, we examined in detail the transcripts induced by p53 expression before the onset of apoptosis

Kornelia Polyak; Yong Xia; Jay L. Zweier; Kenneth W. Kinzler; Bert Vogelstein

2002

Scholarcy highlights

  • The inactivation of the p53 gene in a large proportion of human cancers has inspired an intense search for the encoded protein's physiological and biological properties
  • Of 7,202 transcripts identified, only 14 were found to be markedly increased in p53-expressing cells compared with control cells
  • K.P. is a research associate and B.V. is an investigator of the Howard Hughes Medical Institute

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