Continuous c-fos expression precedes programmed cell death in vivo

Using a fos-lacZ transgenic mouse6, we provide evidence showing that the continuous expression of Fos, beginning hours or days before the morphological demise of the cell, appears to be a hallmark of terminal differentiation and a harbinger of death

Richard J. Smeyne; Montserrat Vendrell; Michael Hayward; Suzanne J. Baker; Graham G. Miao; Karl Schilling; Linda M. Robertson; Tom Curran; James I. Morgan

2003

Scholarcy highlights

  • THE development of a multicellular organism involves a delicate balance among the processes of proliferation, differentiation and death
  • Selective cell death contributes to the formation and organization of the spinal cord and sympathetic ganglia1, retina2 and corpus callosum3
  • An elucidation of the mechanisms responsible for cell death is critical for an appreciation of both normal development and neuropathological disorders
  • Using a fos-lacZ transgenic mouse6, we provide evidence showing that the continuous expression of Fos, beginning hours or days before the morphological demise of the cell, appears to be a hallmark of terminal differentiation and a harbinger of death

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