Superoxide dismutase as a target for the selective killing of cancer cells

We report that certain oestrogen derivatives selectively kill human leukaemia cells but not normal lymphocytes

Peng Huang; Li Feng; Elizabeth A. Oldham; Michael J. Keating; William Plunkett


Scholarcy highlights

  • Superoxide dismutases are essential enzymes that eliminate superoxide radical and protect cells from damage induced by free radicals
  • Using complementary DNA microarray and biochemical approaches, we identify SOD as a target of this drug action and show that chemical modifications at the 2-carbon of the derivatives are essential for SOD inhibition and for apoptosis induction
  • Our results indicate that targeting SOD may be a promising approach to the selective killing of cancer cells, and that mechanism-based combinations of SOD inhibitors with free-radical-producing agents may have clinical applications

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