Small G proteins are expressed ubiquitously in lymphoid cells and do not correspond to Bcl-2

Our results show that small Mr G proteins are widely expressed in lymphoid cells and that Bcl-2 is not a novel member of this GTP-binding protein family

Katherine Monica; Zehava Chen-Levy; Michael L. Cleary

2003

Key concepts

Scholarcy highlights

  • Small G proteins are expressed ubiquitously in lymphoid cells and do not correspond to Bcl-2
  • THE bcl-2 gene is consistently associated with t(14; 18) chromosomal translocations observed in a large fraction of human B-cell lymphomas
  • Gene transfer studies suggest a role for Bcl-2 in cell survival, growth enhancement and oncogenic transformation
  • Electrophoretic and cell-fractionation techniques, we separated Bcl-2 from G proteins of small relative molecular mass and showed that it is incapable of binding GTP
  • Our results show that small Mr G proteins are widely expressed in lymphoid cells and that Bcl-2 is not a novel member of this GTP-binding protein family

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