Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms

We report the first use of a complete restriction fragment length polymorphisms10 linkage map to resolve quantitative traits into discrete Mendelian factors, in an interspecific back-cross of tomato

Andrew H. Paterson; Eric S. Lander; John D. Hewitt; Susan Peterson; Stephen E. Lincoln; Steven D. Tanksley

2003

Scholarcy highlights

  • The conflict between the Mendelian theory of participate inheritance1 and the observation of continuous variation for most traits in nature was resolved in the early 1900s by the concept that quantitative traits can result from segregation of multiple genes, modified by environmental effects2–5
  • Pioneering experiments6–9 showed that linkage could occasionally be detected to such quantitative trait loci, accurate and systematic mapping of QTLs has not been possible because the inheritance of an entire genome could not be studied with genetic markers7
  • We report the first use of a complete restriction fragment length polymorphisms10 linkage map to resolve quantitative traits into discrete Mendelian factors, in an interspecific back-cross of tomato
  • This approach is broadly applicable to the genetic dissection of quantitative inheritance of physiological, morphological and behavioural traits in any higher plant or animal

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