Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF

By using an in vitro cytotoxicity assay with NIH 3T3 and Fisher BRK-derived cells expressing exogenously introduced oncogenes, we found that adenovirus E1A proteins induce susceptibility to tumour necrosis factor killing

Mann-Jy Chen

2003

Scholarcy highlights

  • Tumour necrosis factor α, synthesized primarily by monocytes in response to various invasive agents, induces a wide variety of biological effects relevant to regulating cell growth and differentiation, including the selective killing of some tumour cells and the growth stimulation of some normal fibroblasts
  • As tumour necrosis factor appears to kill tumour cells preferentially, we asked whether TNF sensitivity correlates with the expression of specific oncogene(s)
  • By using an in vitro cytotoxicity assay with NIH 3T3 and Fisher BRK-derived cells expressing exogenously introduced oncogenes, we found that adenovirus E1A proteins induce susceptibility to TNF killing

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