Abrin and Ricin: New Anti-tumour Substances

Abrin and ricin are highly toxic proteins isolated and crystallized from Abrus precatorius and Ricinus communis respectively

JUNG-YAW LIN; KOU-YI TSERNG; CHI-CHING CHEN; LEE-TZU LIN; TA-CHENG TUNG

2005

Scholarcy highlights

  • Abrin and ricin are highly toxic proteins isolated and crystallized from Abrus precatorius and Ricinus communis respectively
  • The inhibitory effect of abrin and ricin on Ehrlich ascites tumour has been demonstrated by simultaneous injection of a sublethal dose with the tumour cells
  • Total inhibition of tumour growth in mice was demonstrated by measurements of body weight and total cell numbers in the peritoneal cavity
  • The therapeutic index of abrin was found to be 4. These inhibitory effects can be eliminated by heating the phytotoxin solution at 100° C for 30 min, which indicates that the anti-tumour activity of phytotoxins is due to protein

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