Near-Infrared Fluorescent NanoGUMBOS for Biomedical Imaging

We report on near infrared fluorescent nanoparticles generated from an emergent class of materials we refer to as a Group of Uniform Materials Based on Organic Salts

David K. Bwambok

2009

Scholarcy highlights

  • We report on near infrared fluorescent nanoparticles generated from an emergent class of materials we refer to as a Group of Uniform Materials Based on Organic Salts
  • We have recently developed an emergent class of highly promising nano-materials we will collectively refer to as GUMBOS
  • All GUMBOS obtained were characterized by nuclear magnetic resonance and elemental microanalysis and yielded results consistent with expectations and the data is provided in the supporting information
  • Our approach alleviates current problems associated with dye leakage and other challenges encountered in dye encapsulation, as well obviating intensive purification steps required when surfactants are used to prepare dye nanoparticles
  • Even more exciting is the prospect of tailoring nanoGUMBOS for delivery into designated cellular structures
  • Examination of the data presented for these cellular studies highlights a new potential for biomedical imaging using NIR fluorescent nanoGUMBOS
  • The nanoGUMBOS were prepared from GUMBOS using a modified simple, additive-free reprecipitation method similar to that used for organic nanoparticles. In a typical preparation, 100 μL of a 1 mM solution of GUMBOS precursor dissolved in ethanol was rapidly injected into 5 mL of triply-deionized water in an ultrasonic bath, followed by further sonication for 2 min

Need more features? Save interactive summary cards to your Scholarcy Library.