In Vivo Biodistribution and Toxicology of Carboxylated Graphene Quantum Dots

We first studied the in vivo biodistribution and the potential toxicity of carboxylated photoluminescent graphene quantum dots

Md Nurunnabi; Zehedina Khatun; Kang Moo Huh; Sung Young Park; Dong Yun Lee; Kwang Jae Cho; Yong-kyu Lee

2013

Scholarcy highlights

  • Photoluminescent graphene quantum dots have fascinating optical and electronic properties with numerous promising applications in biomedical engineering
  • We first studied the in vivo biodistribution and the potential toxicity of carboxylated photoluminescent graphene quantum dots
  • The carboxylated GQDs are desirable for increased aqueous solubility
  • All cancer cells efficiently took up the carboxylated GQDs
  • The toxicity results from serum biochemistry and complete blood count study revealed that the GQDs do not cause appreciable toxicity to the treated animals
  • With adequate studies of toxicity, both in vitro and in vivo, photoluminescent GQDs may be considered for biological application

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