Aqueous-Core Lipid Nanocapsules for Encapsulating Fragile Hydrophilic and/or Lipophilic Molecules

This paper presents the original method of producing aqueous-core lipid nanocapsule, able to encapsulate both hydrophilic and lipophilic species with relevant yields

Nicolas Anton

2009

Scholarcy highlights

  • This paper presents the original method of producing aqueous-core lipid nanocapsule, able to encapsulate both hydrophilic and lipophilic species with relevant yields
  • The scope offered by the integration of both hydrophilic and lipophilic molecules within the same colloidal objects make this method a prime candidate for the numerous anticancer therapies for which chemotherapy frequently requires the association of several molecules
  • The proof of concept study is proposed here describing in detail the formulation of such objects and their characterization, showing the encapsulation of hydrophilic species alone, using examples of very different molecular weights, such as a dye and a protein, and showing the simultaneous encapsulation of hydrophilic and lipophilic species

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