Laser Desorption/Ionization Mass Spectrometric Assay for Phospholipase Activity Based on Graphene Oxide/Carbon Nanotube Double-Layer Films

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Jieon Lee; Young-Kwan Kim; Dal-Hee Min

2010

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  • A new method for quantitative phopholipase activity assays using mass spectrometry and a supported thin film consisting of a graphene oxide/carbon nanotube double layer as a substrate for laser desorption ionization has been developed
  • The rate of lipid hydrolysis was conveniently measured using LDIāˆ’TOF mass spectra obtained from a GO/CNT surface on which the phospholipid hydrolysis reaction mixtures had been spotted by comparing the mass-peak intensities of reactants and products
  • The present platform for phospholipase assays based on MS and GO/CNT double-layer films enables quantitative measurements at low cost, allows assays to be performed in a short time, and is compatible with an array format, unlike conventional assay methods
  • Preparation of the Hybrid Film of Poly(allylamine hydrochloride)-Functionalized Graphene Oxide and Gold Nanoparticle and Its Application for Laser-Induced Desorption/Ionization of Small Molecules

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