Organochlorine Compounds, Iodine Intake, and Thyroid Hormone Levels during Pregnancy

Our results indicate that exposure to organochlorine compounds during pregnancy can alter TH levels

Mar Alvarez-Pedrerol; Mònica Guxens; Jesús Ibarluzea; Marisa Rebagliato; Àgueda Rodriguez; Mercedes Espada; Fernando Goñi; Mikel Basterrechea; Jordi Sunyer


Key concepts

Scholarcy highlights

  • The effect of organochlorine compounds on thyroid function, as well as the potential confounding effect of iodine intake, was studied in a large sample of pregnant women from two population-based cohort studies in Sabadell and Gipuzkoa, Spain
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  • Urinary iodine concentration was measured and iodine intake from diet, iodized salt, and supplements were estimated from a food frequency questionnaire
  • Levels of HCB and PCBs congeners 180, 153, and 138 were related to lower total T3 levels: −4.0(1.1), −6.1(1.6), −5.5(1.6), and 3.8(1.4), respectively) and higher free T4 levels: 0.013(0.005), 0.017(0.007), 0.016(0.007), and 0.007(0.006), respectively). These associations were homogeneous in both cohorts, especially for PCBs and total T3
  • Iodine intake and UIC did not affect the association between OCs and thyroid hormones
  • Our results indicate that exposure to OCs during pregnancy can alter TH levels
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