Why is Chitosan Mucoadhesive?

We have examined the role of primary amino groups and the role of electrostatic attraction, hydrogen bonding, and hydrophobic effects on aggregation of gastric mucin in the presence of chitosan

Ioannis A. Sogias


Scholarcy highlights

  • Chitosan is a biocompatible and biodegradable amino polysaccharide, which is soluble in aqueous solutions at pH < 6.5
  • We demonstrated that electrostatic attraction forces between chitosan and gastric mucin can be suppressed in the presence of 0.2 mol/L sodium chloride; this does not prevent the aggregation of mucin particles in the presence of this biopolymer
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