Carbon Dots from Sugars and Ascorbic Acid: Role of the Precursors on Morphology, Properties, Toxicity, and Drug Uptake

To favor the formation of biocompatible nanostructures suitable for medical applications and to avoid the formation of harmful chemical compounds, in this work we describe the hydrothermal synthesis of carbon dots starting from fructose, glucose, and ascorbic acid, without any passivating or doping additives

Simone Cailotto; Emanuele Amadio; Manuela Facchin; Maurizio Selva; Enrico Pontoglio; Flavio Rizzolio; Pietro Riello; Giuseppe Toffoli; Alvise Benedetti; Alvise Perosa

2018

Scholarcy highlights

  • Based on their optical, physical, chemical, and biological properties, carbon dots have been proposed as nanotheranostic agents for combined cancer therapy and diagnostics. their high water solubility, biocompatibility, low toxicity, good cell permeability, excellent fluorescent imaging sensitivity, and easy conjugation with therapeutics indicate that CDs are ideal candidates as bioimaging probes and theranostic nanocarriers
  • This Letter describes a systematic study on the effect of glucose, fructose, and ascorbic acid as starting materials for the preparation of highly luminescent CDs, characterized by a blue emission
  • Their composition and morphology are investigated by titration of OH surface groups, spectroscopic techniques, and high-resolution transmission electron microscopy, and their toxicity was tested toward HeLa cells
  • CDs made using fructose were toxic, while those made from glucose and ascorbic acid showed good biocompatibility
  • To favor the formation of biocompatible nanostructures suitable for medical applications and to avoid the formation of harmful chemical compounds, in this work we describe the hydrothermal synthesis of CDs starting from fructose, glucose, and ascorbic acid, without any passivating or doping additives
  • The G−CDs, F−CDs, and A−CDs were synthesized by thermolysis of an aqueous solution of glucose, fructose, or ascorbic acid at 200 °C for 24 h in autoclave
  • Syntheses of the carbon dots, hydroxyl value quantification, CDs−doxorubicin interaction quenching, 1H and 13C NMR spectra and Diffusion-ordered NMR spectroscopy of CDs, IR characterization and HV values, and polydispersity index

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