Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules

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Xiaona Li; Zirui Lü; Cong Wang; Kebin Li; Fengrong Xu; Ping Xu; Yan Niu

2021

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  • The abnormally high expression of glutathione transferases is closely associated with cancer incidence and drug resistance
  • By introducing a hydrophobic moiety to the inhibitor structure, we organized a series of degraders of glutathione transferases and demonstrated them potently inducing apoptosis in cancer cells, presenting their pharmacological potential in cancer therapy
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