Resorufin Enters the Photodynamic Therapy Arena: A Monoamine Oxidase Activatable Agent for Selective Cytotoxicity

A red-absorbing, water-soluble, and iodinated resorufin derivative that can be selectively activated with a monoamine oxidase enzyme was synthesized, and its potential as a photodynamic therapy agent was evaluated

Toghrul Almammadov; Gizem Atakan; Ozen Leylek; Gulnihal Ozcan; Gorkem Gunbas; Safacan Kolemen

2020

Scholarcy highlights

  • A red-absorbing, water-soluble, and iodinated resorufin derivative that can be selectively activated with a monoamine oxidase enzyme was synthesized, and its potential as a photodynamic therapy agent was evaluated
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  • R1 showed high 1O2 generation yields in aqueous solutions upon addition of MAO isoforms, and it was further tested in cell culture studies
  • To the best of our knowledge, R1 marks the first example of a resorufin-based photosensitizer as well as the first anticancer drug that is activated by a MAO enzyme
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