Fluorocarbon Gas Exposure Induces Disaggregation of Nanodiamond Clusters and Enhanced Adsorption, Enabling Medical Microbubble Formation

We propose here a simple mean to induce dispersion of NDs in aqueous solutions that does not involve chemical modification of the NDs, which consists in exposing ND dispersions to vapor of a fluorocarbon

Estefania E. Mendoza-Ortega; Marc Dubois; Marie Pierre Krafft

2020

Scholarcy highlights

  • Fluorescent NDs are being investigated as a less-toxic alternative to semiconductor quantum dots
  • We found that 1) exposure to F-hexane or perfluoropentane the adsorption kinetics of both types of NDs at a gas/water interface is markedly impacted by exposure to the FC, both in terms of rate and interfacial tension lowering, and 3)
  • We studied the effect of exposing aqueous dispersions of ND25 and Fluorinated analogs of ND25 to F-hexane and F
  • In order to exploit the observed dispersive effect of FC gases on ND in aqueous dispersions, and influence of their adsorption at an air/water interface, we investigated the possibility of preparing microbubbles that would be shelled by NDs only, that is, without recourse to any conventional surfactant or foaming agent
  • As compared to other techniques of ND disaggregation, our method does not require dry milling or prolonged tip sonication, processes that often produce contaminants that need to be removed by additional purification step
  • More water-soluble FCs deserve investigation in order to enhance the disaggregating effect vis-à-vis other types of NDs. Our data support a novel means of controlling nanodiamond aggregation, as well as a novel approach to stabilize nanodiamond-shelled microbubbles, allowing investigation of their potential as agents for bimodal contrast for ultrasound/fluorescence imaging, and drug delivery

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