Nucleolus-Targeted Red Emissive Carbon Dots with Polarity-Sensitive and Excitation-Independent Fluorescence Emission: High-Resolution Cell Imaging and in Vivo Tracking

Red-emitting carbon dots have attracted tremendous attention due to their wide applications in areas including imaging, sensing, drug delivery, and cancer therapy

Xian-Wu Hua; Yan-Wen Bao; Jia Zeng; Fu-Gen Wu

2019

Scholarcy highlights

  • Red-emitting carbon dots have attracted tremendous attention due to their wide applications in areas including imaging, sensing, drug delivery, and cancer therapy
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  • It is found that the addition of varied metal ions during the hydrothermal treatment of p-phenylenediamine leads to the formation of fluorescent CDs with emission wavelengths up to 700 nm
  • Metal ions play a crucial role in the synthesis of CDs with varied quantum yields, they are absent in the formed CDs, that is, the obtained CDs are metal-free, and the metal ions play a role similar to a “catalyst” during the CD formation
  • In vitro and in vivo experiments demonstrate that Ni–pPCDs are highly biocompatible and can realize real-time, wash-free, and high-resolution imaging of cell nuclei and high-contrast imaging of tumor-bearing mice and zebrafish
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