High Antibacterial Activity of Functionalized Chemically Exfoliated MoS2

This paper reports a proof-of-principle study to evaluate the potential of functionalized two-dimensional chemically exfoliated MoS2 toward inhibitory and bactericidal property against two representative ESKAPE pathogenic strain—a Gram-positive Staphylococcus aureus and a Gram-negative Pseudomonas aeruginosa

Subhendu Pandit; Subbaraj Karunakaran; Sunil Kumar Boda; Bikramjit Basu; Mrinmoy De

2016

Scholarcy highlights

  • In view of the implications of inherent resistance of pathogenic bacteria, especially ESKAPE pathogens toward most of the commercially available antibiotics and the importance of these bacteria-induced biofilm formation leading to chronic infection, it is important to develop new-generation synthetic materials with greater efficacy toward antibacterial property
  • This paper reports a proof-of-principle study to evaluate the potential of functionalized two-dimensional chemically exfoliated MoS2 toward inhibitory and bactericidal property against two representative ESKAPE pathogenic strain—a Gram-positive Staphylococcus aureus and a Gram-negative Pseudomonas aeruginosa
  • The mechanistic study establishes a different extent of oxidative stress together with rapid membrane depolarization in contact with chemically exfoliated MoS2 having ligands of varied charge and hydrophobicity
  • A comparison with widely used small molecules and other nanomaterial-based therapeutics conclusively establishes a better efficacy of 2D ce-MoS2 as a new class of antibiotics
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