Mechanism of Coupling Nanoparticle Stiffness with Shape for Endocytosis: From Rodlike Penetration to Wormlike Wriggling

Nanoparticle -mediated therapies are promising tools for the treatment of a wide range of diseases, including stroke and cancer, due to the outstanding performance they have shown for targeting diseased sites

Ning Liu; Matthew Becton; Liuyang Zhang; Xianqiao Wang

2020

Scholarcy highlights

  • Nanoparticle-mediated therapies are promising tools for the treatment of a wide range of diseases, including stroke and cancer, due to the outstanding performance they have shown for targeting diseased sites
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  • To understand the coupling effect between shape and stiffness of NPs for membrane wrapping, coarse-grained molecular dynamics models with explicit bond, area, volume, and bending stiffness control were constructed for spherocylindrical NPs with identical volumes but different aspect ratios ranging from 1.3 to 11.0
  • Results indicate that the endocytosis time of NPs increases as the aspect ratio increases due to both the increasing surface area and decreasing wrapping rate resulting from the decreasing contact perimeter
  • Our results help gain a deeper understanding of the underlying mechanism of endocytosis of NPs with respect to geometry and particle stiffness, providing a useful guideline for designs of nanoparticles that can be implemented in next-generation nanoparticle-assisted therapy
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