Thyroid Hormone-Disrupting Potentials of Major Benzophenones in Two Cell Lines (GH3 and FRTL-5) and Embryo-Larval Zebrafish

Our results show that these frequently used BPs can alter thyroid hormone balances by influencing the central regulation and metabolism of the hormones

Jungeun Lee; Sujin Kim; Young Joo Park; Hyo-Bang Moon; Kyungho Choi

2018

Scholarcy highlights

  • Benzophenones have been widely used in personal care products such as UV protectants
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  • Zebrafish embryo exposure was conducted for three potent BPs that were identified based on the transcriptional changes observed in the cells
  • In zebrafish embryo assay conducted for BP-1, BP-3, and BP-8, significant decreases in whole-body T4 and T3 level were observed at 6 day postfertilization
  • Our results show that these frequently used BPs can alter thyroid hormone balances by influencing the central regulation and metabolism of the hormones
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