Self-Assembly of Monodisperse Carbon Dots into High-Brightness Nanoaggregates for Cellular Uptake Imaging and Iron(III) Sensing

This study describes a bottom-up assembly route for monodisperse carbon dots into different sizes of CD aggregates through the control of the concentration of fatty acids

Tzu-Heng Chen; Wei-Lung Tseng

2017

Key concepts

Scholarcy highlights

  • This study describes a bottom-up assembly route for monodisperse carbon dots into different sizes of CD aggregates through the control of the concentration of fatty acids
  • The highly monodisperse CDs were prepared via solvent–thermal treatment of edible soybean oil, which generated glycerol-based polymer as a carbon source and fatty acid as a surface capping in the synthetic process
  • The monodisperse CDs can self-assemble into blue, green, yellow, and red-emitting CD aggregates by tuning the concentration of fatty acids
  • We demonstrate the use of filter-free dark-field fluorescence microscopy to dynamically image cellular uptake of the monodisperse CDs in MCF-7 cells and Huh-7 liver cancer cells
  • Without the conjugation of the fluorophore to the CDs, the particle aggregation-induced red-shifted emission enables the development of the CD-based ratiometric sensor for FeIII ions and pyrophosphate based on FeIII-induced aggregation of the monodisperse CDs
  • Such files may be downloaded by article for research use

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