DNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifolia

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Nan Jun Sun; Sung Ho Woo; John M. Cassady; Robert M. Snapka

2002

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  • An ethanol extract of Psoraleacorylifolia caused strong DNA polymerase inhibition in a whole cell bioassay specific for inhibitors of DNA replication enzymes
  • Bioassay-directed purification of the active compounds led to the isolation of the new compound corylifolin and the known compound bakuchiol as DNA polymerase inhibitors
  • Neobavaisoflavone was isolated as a DNA polymerase inhibitor, daidzein as a DNA polymerase and topoisomerase II inhibitor, and bakuchicin as a topoisomerase II inhibitor

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