Carbon Dots as Nontoxic and High-Performance Fluorescence Imaging Agents

The results suggested that the carbon dots were biocompatible, and their performance as fluorescence imaging agents was competitive

Sheng-Tao Yang

2009

Scholarcy highlights

  • Among extensively investigated and currently well-established quantum dots are those based on cadmium selenide in various particle sizes, and their core-shell configurations for improved performance
  • CdSe/ZnS QDs have been demonstrated for superior performance in a number of in vitro and in vivo optical imaging experiments
  • We report results from in vitro and in vivo evaluations confirming that C-Dots are nontoxic, and results from optical imaging in terms of fluorescence microscopy suggesting that C-Dots are competitive in performance to the well-developed CdSe/ZnS QDs
  • The brightness distributions of the two samples obtained, while not different in any substantial fashion, suggested that the C-Dots sample was less homogenous in terms of fluorescence brightness at the individual dot level
  • The oligomeric PEG-functionalized carbon dots were evaluated in vitro and in vivo, from which the results suggested that these fluorescent dots are nontoxic to the selected cell lines, nor do they impose any significant toxic effects on the mice at dosages beyond those commonly used for in vivo optical imaging
  • Organs harvested from the mice exposed to 13C-Dots were homogenized and lyophilized for quantification in terms of the 13C isotopic abundance by using isotope-ratio mass spectroscopy, for which detailed protocols for measurements and data processing are already available in the literature.3031

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