A General Model for Selectivity in Olefin Cross Metathesis

In recent years, olefin cross metathesis has emerged as a powerful and convenient synthetic technique in organic chemistry; as a general synthetic method, CM has been limited by the lack of predictability in product selectivity and stereoselectivity

Arnab K. Chatterjee; Tae-Lim Choi; Daniel P. Sanders; Robert H. Grubbs

2003

Scholarcy highlights

  • In recent years, olefin cross metathesis has emerged as a powerful and convenient synthetic technique in organic chemistry; as a general synthetic method, CM has been limited by the lack of predictability in product selectivity and stereoselectivity
  • The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online
  • Olefin cross metathesis has emerged as a powerful and convenient synthetic technique in organic chemistry; as a general synthetic method, CM has been limited by the lack of predictability in product selectivity and stereoselectivity
  • When an olefin of high reactivity is reacted with an olefin of lower reactivity, selective cross metathesis can be achieved using feedstock stoichiometries as low as 1:1
  • By employing a metathesis catalyst with the appropriate activity, selective cross metathesis reactions can be achieved with a wide variety of electron-rich, electron-deficient, and sterically bulky olefins
  • Application of this model has allowed for the prediction and development of selective cross metathesis reactions, culminating in unprecedented three-component intermolecular cross metathesis reactions
  • Recent Advances in the Preparation and Application of Allylboron Species in Organic Synthesis

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