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The approach enlists a room temperature heterocyclic azadiene inverse electron demand Diels−Alder reaction of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate with the optically active enol ether 6 bearing the C23 chiral center followed by a reductive ring contraction reaction for formation of an appropriately functionalized pyrrole ring in a key 1,2,4,5-tetrazine → 1,2-diazine → pyrrole reaction sequence
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Journal of the American Chemical Society2014,136 , 11483-11493
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