Identification of 4-Hydroxyheptachlorostyrene in Polar Bear Plasma and Its Binding Affinity to Transthyretin: A Metabolite of Octachlorostyrene?

We report on the identification of the unknown phenolic compound in polar bear plasma, which we hypothesized to be a hydroxylated metabolite of OCS based on preliminary mass spectral evidence

Courtney D. Sandau; Ilonka A. T. M. Meerts; Robert J. Letcher; Alan J. McAlees; Brock Chittim; Abraham Brouwer; Ross J. Norstrom

2002

Scholarcy highlights

  • Polyhalogenated aromatic hydrocarbons have been studied extensively due to their ubiquitous presence in biota
  • Phenolic metabolites of PHAHs isolated from plasma have received particular interest
  • We report on the identification of the unknown phenolic compound in polar bear plasma, which we hypothesized to be a hydroxylated metabolite of OCS based on preliminary mass spectral evidence
  • Other possible sources include emissions from the purification of aluminum with gaseous chlorine in graphite vessels and industrial processes involving the electrolysis of magnesium chloride
  • OCS is generally a low-level environmental contaminant that is usually considered to be of little significance compared to major persistent PHAHs, especially polychlorianted biphenyls
  • The relatively high concentration of 4-OH-HpCS in polar bear plasma compared to other phenolic compounds as well as other major contaminants was unexpected
  • We are presently studying the effects of contaminants and their metabolites on circulating thyroid hormone and vitamin A levels in the polar bear as well as the distribution of 4-OH-HpCS in plasma of other species, to help resolve some of these questions

Need more features? Save interactive summary cards to your Scholarcy Library.