Synthesis of Near-Infrared-Absorbing Nanoparticle-Assembled Capsules

Indocyanine green is an FDA-approved photosensitizer dye used in clinical settings for optical diagnostics and near-infrared laser-based therapy

Jie Yu; Mohammad A. Yaseen; Bahman Anvari; Michael S. Wong

2007

Scholarcy highlights

  • Indocyanine green is an FDA-approved photosensitizer dye used in clinical settings for optical diagnostics and near-infrared laser-based therapy
  • Nanoparticle-assembled capsules are prepared at room temperature, in aqueous solution, and at neutral pH by combining a polyallylamine solution, a phosphate solution, and an aqueous sol of silica nanoparticles; ICG-containing NACs with 0.6−1.0 μm diameter are prepared by adding an ICG solution before the nanoparticle sol
  • ICG-containing NACs are capable of heat generation in response to near-infrared laser irradiation and are stable to multiple photothermal heating cycles
  • Brightfield and confocal images of ICG-NACs prepared with an ICG/amine precursor ratio of 0.04 and PAH-FITC for FITC and ICG; fluorescence and brightfield images of ICG-NACs after incubating at 37 °C for 8 h
  • Such files may be downloaded by article for research use

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