Synthesis of Linear, β-Cyclodextrin-Based Polymers and Their Camptothecin Conjugates

The rates of CPT release from the conjugates HGGG6 and HG6 in either mouse or human plasma are dramatically accelerated over the rates of pure hydrolysis at pH = 7.4, indicating the presence of enzymatic cleavage as a rate-determining step at this pH in the release of the CPT

Jianjun Cheng

2003

Scholarcy highlights

  • The rates of CPT release from the conjugates HGGG6 and HG6 in either mouse or human plasma are dramatically accelerated over the rates of pure hydrolysis at pH = 7.4, indicating the presence of enzymatic cleavage as a rate-determining step at this pH in the release of the CPT
  • The pH of aqueous solution has a large effect on hydrolysis rate of CPT from HGGG6 and HG6; the lower the pH, the slower the rate in the range at 4.1 ≤ pH ≤ 13.1
  • The parent polymer 2e has very low toxicity to all cultured cells tested

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