Comparison of the effects of four commercially available weight-loss programmes on lipid-based cardiovascular risk factors

Overall, these results demonstrate the favourable effects of weight loss on lipid-mediated CVD risk factors that can be achieved through commercially available weight-loss programmes

LM Morgan; BA Griffin; DJ Millward; A DeLooy; KR Fox; S Baic; MP Bonham; JMW Wallace; I MacDonald; MA Taylor; H Truby


Scholarcy highlights

  • The current paper reports the effects of these diets on plasma lipid and lipoproteins as markers of CVD risk
  • Subjects and design Three hundred overweight and obese men and women were recruited via a BBC advertising campaign at five university centres across the UK, i.e. Surrey, Nottingham, Ulster, Bristol and Edinburgh
  • Plasma LDL cholesterol concentrations decreased significantly in the Weight Watchers, Slim-Fast and Rosemary Conley groups after 6 months compared with basal values, but were unchanged for the Atkins group
  • While the effects of the four diets on LDL-C were unrelated to LDL particle size, the reductions in plasma TAG after 6 months were respectively three- and ninefold greater in subjects with a predominance of small, dense LDL at baseline on the Atkins and Weight Watchers diets
  • Weight loss was significantly associated with changes in insulin, glucose and in the lipid profile at 6 months
  • While the present study showed all diets to be equal in their ability to promote weight loss, there was some disparity in their effects on blood lipids and lipoproteins
  • Significantly greater reductions in plasma TAG were associated with a predominance of small, dense LDL particles in both the Atkins and Weight Watchers groups at baseline

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