Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

To proceed at a high rate, phosphorylating respiration requires ADP to be available

Vladimir P. Skulachev

2009

Scholarcy highlights

  • To proceed at a high rate, phosphorylating respiration requires ADP to be available
  • In the resting state, when the energy consumption is low, the ADP concentration decreases so that phosphorylating respiration ceases. This may result in an increase in the intracellular concentrations of O2 as well as of one-electron O2 reductants such as These two events should dramatically enhance non-enzymatic formation of reactive oxygen species, i.e. of, and OHׁ, and, the probability of oxidative damage to cellular components
  • It is proposed that some increase in the H+ leak of mitochondrial membrane in State 4 lowers, stimulates O2 consumption and decreases the level of which otherwise accumulates and serves as one-electron O2 reductant
  • The role of natural uncouplers, recouplers, non-specific pore in the inner mitochondrial membrane, and apoptosis, as well as of non-coupled electron transfer chains in plants and bacteria will be considered
  • Chemiosmotic concept of the membrane bioenergetics: what is already clear and what is still waiting for elucidation?J

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