Rapid visual information processing as a cognitive endophenotype of attention deficit hyperactivity disorder

We examined sustained attention and reaction time in youths with attention deficit hyperactivity disorder, unaffected siblings and controls to test whether impaired performance in attention tasks can be a potential endophenotype of ADHD.MethodWe recruited 438 probands with clinical diagnosis of ADHD according to DSM-IV criteria, 180 unaffected siblings, and 173 healthy controls without lifetime ADHD

S. S.-F. Gau


Scholarcy highlights

  • Compared with the controls, probands with attention deficit hyperactivity disorder and unaffected siblings had significantly higher total misses, lower probability of hits in the Rapid Visual Information Processing task and probands with ADHD performed worse in the Reaction Time and Match to Sample Visual Search tasks after controlling for sex, age, co-morbidity, parental educational levels and IQ
  • Our findings suggest that attention performance assessed by the RVP task, but not the RTI or MTS tasks, of the Cambridge Neuropsychological Test Automated Battery may be a useful cognitive endophenotype for ADHD genetic studies
  • Journal of Child Psychology and Psychiatry37, 971–987.CrossRefGoogle ScholarPubMed

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