Exposure to monocrotophos pesticide causes disruption of the hypothalamic–pituitary–thyroid axis in adult male goldfish (Carassius auratus)

The results showed that MCP exposure induced the hyperplasia and hypertrophy of thyroid follicular epithelium and led to decreased plasma total T3 levels and TT3-to-total T4 ratios, without effect on plasma TT4 levels

Xiaona Zhang; Hua Tian; Wei Wang; Shaoguo Ru

2013

Scholarcy highlights

  • The thyroid hormones 3,3′,5-triiodo-l-thyronine and l-thyroxine exert a wide range of biological effects on physiological processes of fish
  • To elucidate the thyroid disruption effects of monocrotophos, an organophosphate pesticide, on male goldfish, thyroid follicle histology, plasma total T3, total T4, free T3 and free T4 levels, and the mRNA expression of indices involved in the hypothalamic–pituitary–thyroid axis were examined following 21-day exposure to 0.01, 0.10 and 1.00 mg/L of a 40% MCP-based pesticide
  • The results showed that MCP exposure induced the hyperplasia and hypertrophy of thyroid follicular epithelium and led to decreased plasma TT3 levels and TT3-to-TT4 ratios, without effect on plasma TT4 levels
  • As a compensatory response to decreased T3 levels, pituitary thyroid-stimulating hormone β subunit mRNA transcription was up-regulated by the MCP pesticide
  • The MCP pesticide exhibited thyroid-disrupting effects via interference with the HPT axis at multiple potential sites, resulting in disturbance of thyroid hormones homeostasis

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