Zebrafish as a model to study peripheral thyroid hormone metabolism in vertebrate development

Intracellular thyroid hormones action is regulated by transporters, deiodinases and receptors

Marjolein Heijlen; Anne M. Houbrechts; Veerle M. Darras

2013

Scholarcy highlights

  • Intracellular thyroid hormones action is regulated by transporters, deiodinases and receptors
  • THs and their regulators are present from the start of zebrafish development
  • Ease of gene silencing makes zebrafish a good model to unravel the role of TH metabolism in vertebrate development
  • Transcripts of all identified genes are present during embryonic development and several of them show dynamic spatio-temporal distribution patterns
  • The recently available tools for targeted stable gene knockout will further increase the value of zebrafish to study the role of peripheral TH metabolism in pre- and post-hatch/post-natal vertebrate development

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