Thyrotropin in teleost fish

We review recent studies indicating that TSH structure is highly conserved across species representing six teleost families

Duncan S. MacKenzie; Richard A. Jones; Thomas C. Miller

2008

Scholarcy highlights

  • Thyrotropin, a pituitary glycoprotein hormone that stimulates the thyroid gland, has been cloned and sequenced from over a dozen teleost fish species
  • TSH is established as a primary driver of systemic thyroid status in mammals, its importance in the regulation of fish thyroid function is still uncertain
  • We review recent studies indicating that TSH structure is highly conserved across species representing six teleost families
  • These studies have found TSH messenger RNA consistently expressed in teleost pituitary tissue, ectopic expression, in gonads, has been observed
  • Descriptive studies have found increased TSH╬▓ expression associated with life history events thought to be promoted by thyroid hormones
  • The relative importance of central pathways in regulating thyroid hormone provision to targets and the identity of a proposed thyrotropin-inhibiting factor in teleost fish are still unanswered questions whose resolution will be facilitated by development of methods to measure circulating TSH and its secretion from the pituitary gland

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