Organopalladium Intermediates in Coordination-Directed C(sp3)-H Functionalizations

This review presents a comprehensive analysis of such organopalladium intermediates involved in site-selective C(sp3)-H functionalizations, emphasizing their intricate structure–function relationships

Anjana Sarala Suseelan; Arnab Dutta; Goutam Kumar Lahiri; Debabrata Maiti

2020

Scholarcy highlights

  • Palladium is the most widely used metal catalyst for coordination-directed C(sp3)-H functionalization and most of these reactions proceed via the formation of palladacycle intermediates
  • Palladium-based complexes are reckoned as front-runners for this purpose, primarily due to their low activation barrier during redox state shuffling
  • Exquisite stereoselective C-H activation remains a synthetic issue for Pd-catalysts
  • This review presents a comprehensive analysis of such organopalladium intermediates involved in site-selective C(sp3)-H functionalizations, emphasizing their intricate structure–function relationships
  • Et al A steric tethering approach enables palladium-catalyzed C–H activation of primary amino alcohols.Nat. Chem

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