Thinking outside the F-box: novel ligands for novel receptors

This review focuses on very recent studies indicating that some F-box proteins function as phytohormone or light receptors, which directly perceive signals and facilitate specific target-protein degradation to regulate downstream pathways

David E. Somers; Sumire Fujiwara

2009

Scholarcy highlights

  • The importance of regulated proteolysis in the physiology and development of plants is highlighted by the large number of genes dedicated to proteasome-dependent protein degradation
  • Within the SCF class of E3 ubiquitin ligases are more than 700 F-box proteins that act as recognition modules to target their dedicated substrates for ubiquitylation
  • This review focuses on very recent studies indicating that some F-box proteins function as phytohormone or light receptors, which directly perceive signals and facilitate specific target-protein degradation to regulate downstream pathways
  • If this new connection between ligand-regulated proteolysis and signaling proves to be more extensive, an entirely new way of understanding the control of signal transduction is in the offing
  • We recommend that commenters identify themselves with full names and affiliations

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