Lead (Pb) exposure induces dopaminergic neurotoxicity in Caenorhabditis elegans: Involvement of the dopamine transporter

This study investigated the effect of Pb exposure on dopaminergic neurodegeneration and function, as well as expression level of several dopaminergic signaling genes in wild type and protein kinase C mutant Caenorhabditis elegans

Ayodele Jacob Akinyemi; Mahfuzur R. Miah; Omamuyovwi M. Ijomone; Aristidis Tsatsakis; FĂ©lix Alexandre Antunes Soares; Alexey A. Tinkov; Anatoly V. Skalny; Vivek Venkataramani; Michael Aschner


Scholarcy highlights

  • In humans, dopaminergic neurotransmission is linked with several behaviour such as locomotion, motivation and recognition activity
  • One-way analysis of variance revealed that Pb exposure caused a significant increase in dat-1 gene expression level at 2.5 and 5 mM when compared with control without Pb treatment for wild-type N2 worms, but no alteration was observed for the mutant strains
  • Several studies have highlighted the neurotoxic potential of Pb exposure in children and adults
  • We demonstrated for the first time, the ability of Pb to interfere with the dopamine transporter via protein kinase C activation in C. elegans model
  • According to McDonald et al, the dopaminergic systems of C. elegans are orthologues to humans given that they harbor the same genes responsible for DA synthesis, storage, release, re-uptake and signaling
  • The present study demonstrated that Pb exposure increased dat-1 gene expression level in wild-type N2 worms, but no alteration was observed for pkc-1 and pkc-2 mutant strains

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